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Medecines and Health products sciences mention

Master 2 Pharmacokinetic/Pharmacodynamic Modelling

Université Toulouse III - Paul Sabatier UFR des Sciences Pharmaceutiques

The course

 

Le master 2 PK/PD modelling propose aux étudiants l’acquisition de compétences nécessaires à la réalisation des travaux en analyse de données pharmacocinétiques et/ou pharmacodynamiques pour intégrer les Unités de Pharmacométrie dans les secteurs industriels ou académiques.

Online registration

Pace of learning

Septembre à janvier : 1 semaine en entreprise / 3 semaines en formation
A partir de début février : Temps plein en entreprise

Course duration

412 heures
12 mois

Teaching methods

Cours, ED, travaux de groupe, analyse de données PK/PD

Knowledge control

Examen écrit, contrôle continu ou final selon les UEs, présentation de projet, mémoire avec soutenance devant un jury multidisciplinaire

The professions associated.

See all professions

Our apprenticeships offer training in development, production, quality, regulatory affairs, legal affairs, health economics, clinical research, pharmacovigilance and marketing.

The program

Le master PK/PD modelling propose 412 heures de formation sur 12 mois avec une majorité des enseignements dispensés en anglais.

Course Unit (CU) : Analysing of individual PK data

  • Linear PK concept
  • Model-dependent analysis : main models, mathematical concepts
  • NCA (non-compartmental analysis)
  • « Two-stage approach » et clinical trials

     Patients with impaired renal or hepatic function, elderly, pediatrics, drug-drug interactions

  • Analytical issues : assay validation
  • PK and drug regulatory (human and veterinary drugs) : Bioequivalence
  • Applied exercises : Personal tasks

CU: Population PK analysis

  • Concepts and methodologies in POP-PK
  • Use of NONMEM, MONOLIX, R (tutorial classes)
  • Applied exercises: 1 ECTS (Personal tasks)
  • POP-PK applied to Therapeutic Drug Monitoring, medical imagery
  • Machine learning applied to PK: 0.5 ECTS

CU: Pharmacokinetic/Pharmacodynamics Modelling (PK-PD)

  • Building of PK/PD models
  • Pharmacodynamics and different kinds of models
  • PK/PD analysis of data (applied exercises)
  • PK/PD workshop

CU : Pre- and post-processing

  • Pre-processing
  • Data management
  • Building of dataset
  • Post-processing / data science
  • Applied exercises : models evaluations, goodness-of-fit (R)
  • Data simulations

CU : Physiologically based PK modelling (PB/PK)

  • Principles of PB/PK
  • Applications of PB/PK : interspecies extrapolations, in vitro/in vivo extrapolations
  • Building a PB/PK model from physiological parameters and drug characteristics
  • Simulations and interpretations

CU : Applications of PK/PD

  • Regulatory for human and veterinary drugs : bioequivalence
  • Veterinary drugs
  • PK/PD of antibiotics
  • PK/PD in oncology

CU : Project development

 

Les personnes en situation de handicap souhaitant suivre cette formation sont invitées à nous contacter directement afin d’étudier ensemble les modalités d’accès requises.

Key figures

Ouverture en 2023-2024 : données disponibles en fin 2024

Admission requirements

 

Etre âgé(e) de moins de 30 ans (hors cas dérogatoires) pour bénéficier d’un contrat d’apprentissage et avoir validé :

Une 5eme année de pharmacie ou école vétérinaire

Ou un Master 1 avec bases en pharmacologie, mathématiques ou statistiques

Les étudiants de plus de 30 ans peuvent bénéficier d’un contrat de professionnalisation.

Disabled people wishing to take this course are invited to contact us directly to discuss the access requirements.

Access to training :

Receipt of applications: the opening dates for applications depend on the course. Please visit the university website to find out the dates. As soon as the dates are set by the university authorities, the CFA presents them on its site and the application is submitted, either on Ecandidat, Apoflux or any other indicated platform.
Course start times: Each course starts differently. On average, it can take from 3 to 7 months from application, selection interviews, confirmation of pre-admission by the educational supervisors, signature of the apprenticeship contract and the start of the course. Depending on the course you wish to follow, you need to calculate the number of weeks between submitting your application and the start of the course, as specified on the website.
Admission process: application and interview.
Apprenticeship or professionalization contract signed with an employer.

Financing :

Within the framework of an apprenticeship or professionalization contract, the cost of training is financed by the France Compétences agency via the company’s OPCO (depending on the collective agreement applied). No training or enrolment fees will be charged to the beneficiary of the apprenticeship or professionalization contract.

The CFA assists companies in having the cost of training covered by the OPCO. Depending on the circumstances, duly indicated on the training form, a remaining charge may be applied over and above the amount financed by France Compétences.

Special conditions for public institutions (contact the appropriate advisor)

 

Selection procedure

File examination and selection interview.
Your privileged contact CFA Leem Apprentissage Ludivine DELPEYROU 06 75 71 91 67
Université Toulouse III - Paul Sabatier UFR des Sciences Pharmaceutiques 35 chemin des Maraîchers 31400 Toulouse
Educational establishment
RESPONSABLES PEDAGOGIQUES Pr Etienne CHATELUT
Pr Alain BOUSQUET-MELOU
This course is certified
Qualiopi
(i) Update : August 2023